
Ketamine-Assisted Mindfulness for Lasting Change
If you’re feeling stuck in anxiety, depression, or unhealthy coping patterns that no longer serve you, this 10-week program offers a supportive path toward greater clarity, compassion, and connection.
Calm Mind Open Heart Ketamine-Assisted Mindfulness
If you've tried therapy, tried medication, tried the things that are supposed to work — and you're still stuck — this program was built with you in mind. CMOH-KAM is a 10-week program that weaves together low-dose ketamine, meditation, breathwork, and ongoing support, with one goal: helping mindfulness become something you actually live, not just something you practice for an hour a week.
While ketamine is part of this program, it isn't what creates the change. Think of it like Miracle-Gro for the brain's ability to grow new patterns — research suggests it may temporarily increase neuroplasticity. But any gardener will tell you that Miracle-Gro alone doesn't grow the garden you want. Walk away after applying it, and you might come back to something beautiful, or you might come back to weeds. This program isn't about applying Miracle-Gro and hoping. It's about learning to use mindfulness as the tools that shape what actually grows — cultivating what's meaningful, and clearing what no longer serves you.
What Makes This Program Different
Most ketamine-assisted therapy programs focus on talking through the ketamine experience afterward — interpreting it, making meaning from it, the way you might explore a dream.
CMOH-KAM takes a different approach. Instead of centering interpretation, we center skill-building. Ketamine becomes a temporary support that softens rigid patterns and makes it easier to practice the habits that lead to real, lasting change, not the thing that does the changing for you.
The program builds four core skills:
Awareness — noticing what's happening in your body, mind, and surroundings more clearly than before
Focus — staying with what actually matters to you, instead of getting pulled away
Regulation — pausing before reacting, instead of running the same automatic pattern
Compassion — meeting yourself with acceptance instead of judgment or self-criticism
Together, these skills help reshape patterns that may have made sense at one point but no longer serve you. Over time, they become reliable inner resources; ways of moving through life with more clarity, more calm, and a more open heart.
What the Program Involves
Over 10 weeks, you'll move through a gentle, structured process built to meet you where you are. No prior meditation or breathwork experience is required — everyone starts from a different place, and the program supports beginners and experienced practitioners alike. A companion workbook walks you through turning these skills into daily habits that feel natural over time.
Throughout the program, you'll engage in:
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Daily meditation and guided pranayama (breathwork) practices
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A step-by-step companion workbook for building mindful habits into your daily life
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Weekly therapeutic sessions to work through barriers and support steady progress
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Six low-dose ketamine-assisted meditation sessions (optional)
The pace is intentionally slow and steady — the goal is change that's meaningful and sustainable well beyond the 10 weeks, not a quick fix.
Who This Program Is For
This might be a fit if you're dealing with depression that hasn't responded to other treatment — sometimes called treatment-resistant depression. Maybe that looks like a low mood that won't lift, a habit of being hard on yourself, losing interest in things that used to matter, or a heaviness that's difficult to name and even harder to shake.
It might also be a fit if you're dealing with anxiety that's stuck around no matter what you've tried — constant worry, a mind that won't settle, a body that stays on alert even when you know there's nothing to be afraid of. Maybe you've done therapy, maybe you've tried medication, and you're still finding yourself caught in the same loops of tension, racing thoughts, or overwhelm.
Ketamine Is Optional, Not Required
The heart of CMOH-KAM is the cultivation of mindfulness-based skills — awareness, focus, regulation, and compassion — built through daily meditation and breathwork. Ketamine is offered as an optional support, not a requirement, because research suggests it may temporarily make it easier to notice thoughts and sensations with openness, which can make habitual patterns easier to recognize and shift. Ketamine is an assist. The practice is what creates lasting change.

Research
As with any powerful therapeutic tool, ketamine-assisted work carries both potential benefits and real risks. That’s why it’s essential that this program is grounded in the emerging research on ketamine-assisted psychotherapy and mindfulness, not just what “feels right” or being overly focused on the evidence where it seems promising.
Evidence-informed care helps to point to developing processes that are thoughtful and aligned with what we currently understand about how change happens. At the same time, it’s important to acknowledge that this form of ketamine-assisted therapy—like all emerging psychedelic approaches—does not offer guaranteed outcomes, and each person’s response is unique. Below you’ll find links to the studies that have shaped and guided the development of this program.
Anxiety
Fumero, A., Peñate, W., Oyanadel, C., & Porter, B. (2020). The Effectiveness of Mindfulness-Based Interventions on Anxiety Disorders. A Systematic Meta-Review. European Journal of Investigation in Health, Psychology and Education, 10(3), 704–719. https://doi.org/10.3390/ejihpe10030052 (PubMed)
Glue, P., et al. (2017). Ketamine’s dose-related effects on anxiety symptoms in patients with severe generalized anxiety disorder or social anxiety disorder: a double-blind, randomized, placebo-controlled trial. Journal of Psychopharmacology, 31(10), 1302–1310. (PubMed)
Hoge, E. A., Bui, E., Mete, M., Dutton, M. A., Baker, A. W., & Simon, N. M. (2023). Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial. JAMA Psychiatry (Chicago, Ill.), 80(1), 13–21. https://doi.org/10.1001/jamapsychiatry.2022.3679 (JAMA Psychiatry)
Mills, N. T., Nikolin, S., Glozier, N., Barton, D., Baune, B. T., Fitzgerald, P. B., Glue, P., Sarma, S., Rodgers, A., Hadzi-Pavlovic, D., Alonzo, A., Dong, V., Martin, D., Mitchell, P. B., Berk, M., Carter, G., Hackett, M. L., Somogyi, A. A., Mihalopoulos, C., Loo, C. K. (2025). Effect of ketamine on anxiety: findings from the Ketamine for Adult Depression Study. British Journal of Psychiatry, 227(3), 601–607. https://doi.org/10.1192/bjp.2024.250 (BJPsych)
Depression
Alkan, E., Kumar, G., Ravichandran, S., Kaushal, S. R., Salazar-de-Pablo, G., Alerci, L., Michaud-Feinberg, J., Gutiérrez-Rojas, L., Zorzi, C., Klauser, P., Golay, P., Kramer, U., & Alameda, L. (2025). Effectiveness of mindfulness based interventions in reducing depressive symptoms across mental disorders: A meta-analysis of randomized controlled trials. Psychiatry Research, 348, Article 116473. https://doi.org/10.1016/j.psychres.2025.116473 (PubMed)
Arabzadeh, S., Hakkikazazi, E., Shahmansouri, N., Tafakhori, A., Ghajar, A., Jafarinia, M., & Akhondzadeh, S. (2018). Does oral administration of ketamine accelerate response to treatment in major depressive disorder? Results of a double-blind controlled trial. Journal of Affective Disorders, 235, 236–241. https://doi.org/10.1016/j.jad.2018.02.056 (PubMed)
Rosenblat, J. D., Carvalho, A. F., Li, M., Lee, Y., Subramanieapillai, M., & McIntyre, R. S. (2019). Oral Ketamine for Depression: A Systematic Review. The Journal of Clinical Psychiatry, 80(3). https://doi.org/10.4088/JCP.18r12475 (PubMed)
Veraart, J. K. E., Smith-Apeldoorn, S. Y., Kamphuis, J., Spijker, J., van der Meij, A., van Asselt, A. D. I., aan het Rot, M., & Schoevers, R. A. (2024). Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension. Molecular Psychiatry, 29(9), 2657–2665. https://doi.org/10.1038/s41380-024-02478-9 (PubMed)
Risk & Safety
Sayad, R., Elsaeidy, A. S., Anis, A. M., Atef, M., Hawash, E. A., Saad, H. A., Hamad, K. A. A., & Kohaf, N. A. (2025). Safety considerations and risk mitigation strategies for ketamine use: a comprehensive review. Annals of Medicine and Surgery, 87(5), 2829–2837. https://doi.org/10.1097/MS9.0000000000003232 (PubMed)